Machine learning algorithm for early-stage prediction of severe morbidity in COVID-19 pneumonia patients based on bio-signals

Abstract Background Paralysis of medical systems has emerged as a major problem not only in Korea but also globally because of the COVID-19 pandemic.Therefore, early identification and treatment of COVID-19 are crucial.This study aims to develop a machine-learning algorithm based on bio-signals that predicts the infection three days in advance befo

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The Crosstalk of Pathways Involved in Immune Response Maybe the Shared Molecular Basis of Rheumatoid Arthritis and Type 2 Diabetes.

Rheumatoid arthritis (RA) and Type 2 diabetes (T2D) are both systemic diseases linked with altered immune response, moderate mortality when present together.The treatment for both RA and T2D are not satisfied, partly because of the linkage between them has not yet Handcream been appreciated.A comprehensive study for the potential associations betwe

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The increase of an allelopathic and unpalatable plant undermines reindeer pasture quality and current management in the Norwegian tundra

Abstract Ongoing Arctic greening can increase productivity and reindeer pasture quality in the tundra.However, greening may also entail proliferation of unpalatable species, with consequences for pastoral social-ecological systems.Here we show extensive greening across 20 reindeer districts in Norway between 2003 and 2020, which has reduced pasture

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Activation of exchange protein activated by cAMP in the rat basolateral amygdala impairs reconsolidation of a memory associated with self-administered copyright.

The intracellular mechanisms underlying memory reconsolidation critically involve cAMP signaling.These events were originally attributed to PKA activation by cAMP, but the identification of Exchange Protein Activated by cAMP (Epac), as a distinct mediator of cAMP signaling, suggests that cAMP-regulated processes that subserve memory reconsolidation

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